30篇關於通過長期飼養評估轉基因食品的慢性影響的研究

轉基因 飼料 腫瘤 畜牧業 溫酒斬華滕 2018-12-12

30篇關於通過長期飼養評估轉基因食品的慢性影響的研究

Feeding studies for assessing chronic effects of transgenic food by length of feeding time or nature of analysis

本文摘自How safe does transgenic food need to be?

DeFrancesco, Laura. How safe does transgenic food need to be?[J]. Nature Biotechnology, 2013, 31(9):794-802.

轉基因的安全性一直是大家討論的重點,而在歐盟,除了西班牙之外,其他國家都禁止轉基因的種植,我國也只是批准了少量轉基因品種的種植,並且對含轉基因成分食品要求強制標識,本文整理了關於轉基因研究的30篇文獻,轉基因是否有害,還請各位見仁見智。

如果大家想要閱讀其中的文獻,而又不知道怎麼下載,可以私聊發送鏈接!

30篇關於通過長期飼養評估轉基因食品的慢性影響的研究

幾個注射器粘在西紅柿上。轉基因概念產品

30篇關於通過長期飼養評估轉基因食品的慢性影響的研究

圖片摘自:坤園自留地

30篇關於通過長期飼養評估轉基因食品的慢性影響的研究

圖片摘自:註冊營養師

所展示的30篇文獻,研究時間從2個月至3年不等,所表現的結果也不近相同,有的認為無顯著影響,有的認為在一些特徵上有差異,還有的認為對在死亡率和腫瘤率上有顯著差異

參考文獻編號、研究內容及其結果

23:睪丸生殖細胞的影響

結果:睪丸細胞數量、產仔數、體重無差異

24:睪丸生殖細胞的影響

結果:睪丸細胞數量、產仔數、體重無差異

25:生殖組織的組織學

結果:轉基因和有機大豆飲食會導致體重下降、血清甘油三酯、膽固醇、子宮和卵巢形態的改變

26:生長性能,血液學分析,器官重量和組織學分析,

結果:bt餵養母豬後代(脾臟、肝臟較輕,但整體較重)存在一些差異

27:免疫功能,血液學分析

結果:與免疫功能相關的血液化學無差異

28:免疫功能、血液學分析、Cry1Ab抗體生產及毒素分析

結果:轉基因飼料母豬免疫系統紊亂(淋巴細胞增多,紅細胞減少)。但沒有毒素轉移出胃腸道

29:體重,血清化學分析

結果:轉基因母豬比較重,後代較輕,血清化學有一些差異

30:身體組成、器官重量及組織學、尿液生化分析

結果:對生長、器官重量、組織學無影響,血清化學成分有差異

31:髂骨,盲腸和糞便中微生物群相對豐富

結果:除了對健康有未知重要性的一個屬之外,無差異

32:生長速度,蛋白質攝入量,白蛋白水平,血清總蛋白

結果:有機和轉基因飼料比酪蛋白飼料重,蛋白質攝入量低,紅細胞比容低

33:蛋白質有效比、淨蛋白質比和營養效率係數

結果:體重比、蛋白質攝入量和質量存在差異

34:主動脈生長和重量,血脂

結果:沒有區別

35:生長,交配,妊娠,擠奶期,繁殖,壽命

結果:在5代以上的表現沒有顯著的差異,但是後代體重逐漸下降

36:胃、十二指腸、肝、腎、各種代謝產物及蛋白質的組織學

結果:腎臟和肝臟的組織學差異不大

37:淋巴結大小、脾臟、血細胞、免疫表型細胞來自血液和淋巴結

結果:GM-triticale可引起次級淋巴器官b細胞成分的擴大無過敏性、無致癌性

38:上皮的組織學和超微結構特徵,oblet細胞黏液的組織化學模式和大腸菌群的生長情況

結果:衰老過程相似,轉基因對腸道結構無影響,但降低了與飲食有關的黏液蛋白

39:薄層腺泡核的形態學和免疫化學分析

結果:對泛核腺泡細胞hnrNA轉錄後過程有影響

40:肝臟的形態功能特徵

結果:轉基因餵養小鼠肝細胞中hepa- tocyte代謝蛋白、應激反應蛋白、鈣信號蛋白和線粒體蛋白均有差異表達;有絲分裂軸和核的改變表明代謝率降低

41:肝細胞超微結構形態學及免疫細胞化學研究

結果:肝細胞細胞核不規則,核仁不規則,核因子更多

42:胰腺腺泡細胞的超微結構、形態學、免疫細胞化學分析

結果:影響酶原合成和加工

43:肝臟免疫電鏡檢查

結果:逆轉肝細胞有變化

44:Sertoli細胞,精原細胞和精母細胞的免疫電鏡觀察

結果:睪丸細胞的免疫標記有差異

45:壽命,肝臟和腎臟形態

結果:一些轉基因組的死亡率和腫瘤發生率更高

46:體重,食物消耗,生殖性能和器官重量

結果:體重、食用量、生殖性能、器官重量無變化

47:血液學、血清生物化學及病理檢查

結果:體重、食量不變、血液學、血清生化、器官重量不變。腫瘤發生率無增加

48:生長,機體組成,器官發育,血氣邏輯參數,臨床血漿化學和溶酶水平

結果:血漿甘油三酯水平升高,中腸變小;總生長或其他測量參數無差異

49:幹物質攝取量、泌乳量、產奶量

結果:牛奶成分及身體狀況無影響

50:性能,繁殖特性,血液學參數,抗氧化防禦,淋巴細胞增殖能力,巨噬細胞吞噬與細胞內殺傷力,反芻微生物種群特徵

結果:在性能、生殖特徵、血液參數、免疫系統、肝細胞核顯微變化方面無差異

51:酶在血清、心臟、腎臟、骨骼肌、肝臟中的活性

結果:心臟、肌肉、腎臟乳酸脫氫酶活性升高;身體和器官重量無差異

52:細胞和器官顯微鏡和組織學,基因表達模式,產仔數和重量

結果:兩組間繁殖數據差異無統計學意義(表36),但產仔數受傳代次數影響,與GM組相比,ISO組產仔數較多,產仔數為n> 8。雖然GM組的全窩平均質量始終低於ISO組,但差異無統計學意義

30篇關於通過長期飼養評估轉基因食品的慢性影響的研究

How safe does transgenic food need to be?

30篇關於通過長期飼養評估轉基因食品的慢性影響的研究

How safe does transgenic food need to be?

關於參考文獻45:本文被指出試驗設計不嚴謹或存在汙染,已經被撤稿

參考文獻

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